Plasticity refers to the nervous system's ability to change its structure and function in response to intrinsic or extrinsic influences. Plasticity is necessary for healthy brain development and is an important player in brain damage and disease, as too little or too much can underlie the inability of the brain to effectively repair itself. This course will consider recent research into these topics exploring molecular, cellular and circuit-level mechanisms of synaptic and structural plasticity during development and adulthood, under conditions of health as well as damage and disease.